Thesis
Subject: Genetic analysis of a complex trait using transcriptomic data: contribution of gene regulatory network modeling
Biological application: better understand the fatness variability particularly in meat chickens.
Research topics
- gene dependence in multiple testing
- QTL/eQTL/mQTL analysis
- gene regulatory network
Papers
- Blum Y, Le Mignon G, Causeur D, Filangi O, Désert C, Demeure O, Le Roy P, Lagarrigue S. Complex trait subtypes identification using transcriptome profiling reveals an interaction between two QTL affecting adiposity in chicken. BMC Genomics, 2011, 12:567
- Blum Y, Le Mignon G, Lagarrigue S, and Causeur D. A Factor Model to Analyze Heterogeneity in Gene Expression. BMC Bioinformatics, 2010, 11:368. Highly Accessed
Communications
Oral communications:
- Blum Y, Houée M, Friguet C, Lagarrigue S & Causeur D- Inférence de réseaux de gènes à partir de données transcriptomiques. Séminaire de Biologie Intégrative et Genomique dans le Grand Ouest, Auray, 7-9 November 2011.
- Blum Y., Demeure O., Désert C., Guillou H., Bertrand-Michel J., Filangi O., Le Roy P., Causeur D., Lagarrigue S. Integrating QTL controlling fatness, lipid metabolites and gene expressions to genetically dissect the adiposity complex trait in a meat chicken cross. 62nd Annual Meeting EAAP. August 2011, Norway Website
- Mach N., Blum Y., Smits M., Causeur D., Lagarrigue S. – Effect of the gene diacylglycerol-O-transferase 1 (DGAT1) polymorphism on the global expression pattern of genes in the mammary gland tissue of dairy cows. 62nd Annual Meeting EAAP. August 2011, Norway
- Houée M., Friguet C., Lagarrigue S., Blum Y., Causeur D. Large-scale significance testing of high-thoroughput Data with FAMT. ASMDA 2011 Conference, Rome, 7-10 June 2011
- Blum Y., Le Mignon G, Causeur D, Pitel F, Demeure O, Filangi O, Le Roy P, Lagarrigue S – Transcriptome profiling reveals interaction between two QTL for fatness in chicken. The 15th QTL-MAS workshop, Rennes, 19-20 May 2011. Website
- Blum Y., Friguet C, Lagarrigue S & Causeur D. Inferring gene networks using a sparse factor model approach: application in a lipid metabolism study, International Biometric Society Channel Network, Bordeaux, 11-13 April 2011. Website
- Blum Y., Lagarrigue S., Causeur D. Genetic analysis of a complex trait using transcriptomic data: contribution of gene regulatory network modeling. Séminaire des Thésards du Département de Génétique Animale INRA, Pornichet, 5-6 April 2011.
- Blum Y, Lagarrigue S & Causeur D – Analyse génétique de caractères complexes, IFR140 Génétique Fonctionnelle, Agronomie et Santé, Rennes, 1srt December, 2010. website
- Blum Y, Lagarrigue S & Causeur D– A factor model to analyze heterogeneity in gene expression in a context of QTL characterization. International Society for Animal Genetics, Edinburgh, 26-30 July 2010. Program Website
- Blum Y, Lagarrigue S & Causeur D – Caractérisation fonctionnelle d’un QTL par prise en compte de la dépendance génique, Journée des Doctorants de Rennes & Brest en Biologie-Santé, Rennes, June 2010.
- Blum Y, Friguet C, Lagarrigue S & Causeur D – Inférence sur réseaux géniques par Analyse en Facteurs. SFdS Marseille, 25-28 May 2010. Program Website
- Blum Y, Lagarrigue S & Causeur D– A factor model to analyze heterogeneity in gene expression in a context of QTL mapping. 8th workshop « Statistical Methods for Post-Genomic Data» Luminy, Marseille, 14-15 January 2010. Program Website
Posters:
- Blum Y, Houée M, Friguet C, Lagarrigue S & Causeur D- Genetic analysis of a complex trait using transcriptomic data: contribution of gene regulatory network modeling. Session “Genes and pathways” Plant&Animal Genome XX, San Diego CA USA, 14-18 January 2012.
- Blum Y- Modélisation de réseaux de gènes : apport dans le déterminisme génétique de caractères complexes. Séminaire des Thésards du Département de Génétique Animale INRA, Pornichet, 6-7 April 2010.
- Blum Y, Lagarrigue S & Causeur D– A factor model to analyze heterogeneity in gene expression in a context of QTL characterization. International Society for Animal Genetics, Edinburgh, 26-30 July 2010.
- Blum Y, Le Mignon G, Causeur D, Pitel F, Demeure O, Filangi O, Le Roy P, Lagarrigue S – Transcriptome profiling reveals interaction between two QTL for fatness in chicken. International Society for Animal Genetics, Edinburgh, 26-30 July 2010.
Awards and grants
- INRA-Agrocampus Ouest Grant to attend the PAG XX workshop (Jan. 2012, San Diego, USA) and presenting the poster “Genetic analysis of a complex trait using transcriptomic data: contribution of gene regulatory network modeling.”
- Mobility Grant from Rennes Metropole: 4 months in Jake Lusis Laboratory at UCLA (Los Angeles, USA) from mid-December to mi-April 2012
- ISAG bursary, International Society for Animal Genetics, Edinburgh, 26-30 July 2010.
- Yoshi Suzuki Award for the best Abstract and Poster - A factor model to analyze heterogeneity in gene expression in a context of QTL characterization – International Society for Animal Genetics, Edinburgh, 26-30 July 2010.
- Prize of the best Poster -Modélisation de réseaux de gènes : apport dans le déterminisme génétique de caractères complexes- Séminaire des Thésards du Département de Génétique Animale INRA, Pornichet, 6-7 April 2010.
Scientific activities
- Member of the organizing committee for the 6th edition of the International Conference CARME at Rennes in Feb. 2011 (140 participants).
- Member of the SIB working group (Statistics for Integrative Biology) which organizes regular seminars.
- Vice president for the Phd students association DocAIR (Feb. to Sept. 2011) which organizes scientific events.
- Member of the organizing committee for the 13th edition Seminar of the INRA Animal Genetics Phd students at Pornichet in April 2010 (71 participants).
